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Dr. Bishnu Sanwal
Affiliation: Western University
Keywords: Glycoproteins, membranes, myogenesis, differentiation, molecular biology
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B.D. Sanwal is a distinguished exponent of the biochemical expression of the mechanisms of regulation and control of enzymes and enzyme pathways. His studies began with the metabolism of plant pathogens ('Fusarium') but by 1960 he became more and more involved in understanding enzyme regulation in 'Neurospora' and bacterial model systems. He has contributed importantly to knowledge of allosteric controls of amphibolic enzymic processes with alternative catabolic or biosynthetic pathways using the same set of enzymes but different initiating substrates. He has not restricted his interests in controls and he is also heavily involved in cytodifferentiation studies using myoblasts and neuroblasts. The clarity of his expression in these areas has been very influential.
Dr. William Sarjeant
Affiliation: University of Saskatchewan
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WILLIAM ANTONY SWITHIN SARJEANT, Professor, Department of Geological Sciences, University of Saskatchewan, has not only published numerous significant articles on fossil vertebrate footprints and fossilized microplankton but also has become a well-known authority on the history of geology. His book on fossil and living dinoflagellates is recognized as a leading text. Publications on acritarchs have received wide acclaim. His international bibliography covers all publications in the Latin alphabet pertinent to the history of geology from its beginnings to 1984. The only one of its kind, and one which has brief biographies of authors as well as references, it has become an invaluable research tool for geologists and historians alike.
Rolf Sattler
Affiliation: McGill University
Keywords: Ken Wilber, logic, mandala, meditation
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Professor Rolf Sattler is a distinguished plant morphologist, internationally recognized for his studies in floral development, his critical analyses of the methods and conclusions of comparative morphology and his interpretations of the relationship between developmental processes and evolutionary changes. In addition to numerous papers he has published a volume of original research which is a major contribution to the field of floral morphogenesis. He has lectured by invitation in numerous universities around the world and has participated in several symposia. In 1974 he was awarded the Lawson Medal by the Canadian Botanical Association.
Dr. Stuart Savage
Affiliation: McGill University
Keywords: Fluid mechanics, granular materials, sea ice dynamics, debris flows
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Professor Savage is well known for work on the flow of bulk solids which has evolved from his earlier research in fluid mechanics.
The present research has a wide application to, for example, avalanches of rocks, mud or snow; gravity flows of grain in hoppers and chutes; filtering of solid particles; slip casting of alumina. He has contributed to the formulation of constitutive relations for stress in particulate flows of high concentration at various rates of shear.
Dr. Savage is an Editor of the new journal "Continuum Mechanics and Thermodynamics".
Dr. Douglas Savile
Affiliation: Agriculture and Agrifood Canada
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Dr. Savile is author or co-author of over 70 research papers in cytology and taxonomy of fungi; taxonomy and biogeography of phanerogams; floristics especially of the Arctic; ornithology; meteorology; microscopic techniques; and principles and processes of evolution. He is Curator of the National Mycological Herbarium and has specialized on rusts and smuts in which he is a recognized authority. He has used his knowledge of the parasitic fungi to elucidate the phylogeny of certain of the host plants. He has carried out extensive biological explorations in the Canadian Arctic. He has made significant contributions in the field of aerodynamics of avian and mammalian flight. He has shown notable ability in the integration and application of data from various disciplines to problems of evolution.
Dr. Michael Sayer
Affiliation: Queen's University
Keywords: Dielectrics, bioceramics, instrumentation, materials
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Professor Michael Sayer, of Queen's University, with research interests in solid state physics, has been a leader in bringing to Canadian industry the results of his scholarship. His research group has produced new knowledge and understanding of ceramic materials and have brought to industrial development acoustic transducers, ferro-electric detectors, thermo-electric power generation materials, superconducting demonstration ceramics for high schools, and recently a sol gel process to make thin film transducers for optical fibers. Dr. Sayer has also created and managed many effective collaborations between industry and university and has encouraged this activity and attitude through his many students and colleagues.
Dr. Juan Scaiano
Affiliation: University of Ottawa
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Dr. J. C. Scaiano is distinguished nationally and internationally for his work on organic reaction intermediates. His outstanding contributions in the fields of excited states, biradicals, free-radicals, radical-pairs, and carbenes have produced a revolution in our understanding of their reactions. His development and application of laser techniques for the study of rapid organic reactions have led to fast and accurate methods for the study of reaction mechanisms and kinetics. His stimulating research on the role of highly reactive intermediates in homogeneous systems, polymers, and molecular aggregates has made him one of Canada's most highly respected and prolific young scientists.
Dr. Harry Schachter
Affiliation: University of Toronto
Keywords: Complex carbohydrates, enzymes, biosynthesis, glycoproteins, cell surfaces
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Dr. Schachter's major concern has been the biological synthesis, by enzymes (glycosyltransferases), of complex carbohydrates, important and unique components of all cell surfaces. He is a major figure in the field, through his research, his guidance of graduate students, and his lectures and written reviews. He was a pioneer with many unique contributions, including the first to localize these enzymes in the Golgi apparatus, thereby pointing to its important role in glycosylation, and the first to systematically isolate and characterize key glycosyltransferases (ten of them) involved in glycan branching and core synthesis, and to delineate the rules which control the synthesis of these highly complex structures. The biochemistry and molecular biology of these enzymes has since become a major field of study by his laboratory and others interested in the functions of complex carbohydrates and in the development of new therapeutic approaches to cancer metastasis, inflammation and other areas of medicine.
Dr. Harold Schiff
Affiliation: Unisearch Associates Ltd.
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H.I. SCHIFF (Chemistry), over a period of some twenty-five years, has made a very significant impact on physical chemistry and has achieved an undoubted international reputation. He has made lasting and important contributions to the measurements of the rates of a considerable number of chemical reactions involving both neutral and charged species, as well as to the determination of bond dissociation energies, of ion appearance potentials, of conductivities, and of diffusion constants. His contributions to the development of techniques to measure trace constituents of the upper atmosphere and to the interpretation of the physics and chemistry of the stratosphere are particularly important from the point of view of the pollution of the stratosphere by supersonic aircraft with potentially serious adverse effects.
Peter Schiller
Affiliation: Université de Montréal
Keywords: Peptides, peptide hormones and neurotransmitters, analgesia, drug design, opioid peptides
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Dr. Schiller is a world leader in peptide chemistry. He has developed new concepts in receptor-selective opioid analogs on the basis of the so-called membrane compartment concept. One of them, carrying a high positive charge, displayed unprecedented µ-selectivity is by far the most selective µ-agonist known to date and appears to have considerable potential for clinical applications. In 1987, he received the Max-Bergmann Medal which is one of the highest recognition in peptide research. He received the Galen Award (Prix Galien) for excellence in pharmaceutical research (1995), an NIH Merit Award (1997) and the Vincent du Vigneaud Award of the American Peptide Society (1998). He was elected a Fellow of The American Association of Pharmaceutical Sicentists in 1998. In 1999, he was appointed "officier" of the Ordre national du Québec".
Dr. David Schindler
Affiliation: University of Alberta
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DAVID W. SCHINDLER founded the Experimental Lakes Project of the Canadian Department of Fisheries and Oceans in 1968. After directing the project for 22 years, he moved to the University of Alberta, where he has been the Killam Memorial Professor of Ecology since 1989. He has received numerous awards for his scientific work, including the first Frank Rigler Award of the Canadian Society of Limnologists, the Hutchinson Medal of the American Society of Limnology and Oceanography, the Naumann-Thienemann Medal of the International Limnological Society, the first Miroslaw Romanowski Medal of the royal Society of Canada, the Manning Award of Distinction for Innovation in Science, the first Stockholm Water Prize, the Volvo Environment Award, and the Gordin Kaplan Award. He has served as the president of the American Society of Limnology and Oceanography. He has received four honorary doctorate degrees from Canadian and American Universities, and was inducted into the Royal Society of Canada in 1983. He has published over 225 papers on a wide variety of topics in aquatic ecology and biogeochemistry, including eutrophication, acid rain, climate warming, and lake restoration.
Dr. Morris Schnitzer
Affiliation: Agriculture and Agrifood Canada
Keywords: Bio oil, bio diesel, mass spectrometry, NMR, nanochemistry
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Dr. M. Schnitzer is the leading world authority on soil organic matter, with emphasis on chemical structure of humic substances, mechanisms of interactions of humic materials with metals and minerals, and the isolation and identification of complex nitrogen compounds from soils. From extensive chemical and spectroscopic studies, he established a novel structural concept for humic materials. His research findings, embodied in 340 refereed papers and a textbook, have had an enormous impact on world agricultural production and environmental protection. In addition, he has edited two books and trained and inspired soil scientists worldwide. His contribution has been recognized by Fellowships in the CSSS, SSSA and the ASA, and the Wolf Prize in 1996.
Dr. Henry Schwarcz
Affiliation: McMaster University
Keywords: Geochemistry, archaeological science, paleoclimate, bone
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H.P. Schwarcz has made numerous and brilliant contributions to geochemistry, quaternary geology and archaeology. Oxygen, sulphur and carbon isotope ratios have been used to interpret the history of metamorphic rocks, sulphide ores and, more recently, cave deposits. The innovative analysis of speleotherm growth rings to measure past climatic temperature, when caves were forming, led him to search for a way to measure their age. This was achieved in the establishment of the first Canadian uranium-series dating laboratory, leading to a series of articles with students and collaborators (notably D.C. Ford) recording climate changes back through the Pleistocene. These successes led in turn to his current collaborations with archaeologists, measuring critical deposits and artifacts to establish an absolute time scale for human pre-history. He has a wide diversity of interests and brings a fertile creative mind and a warm human enthusiasm to all his activities.
Dr. Steven Scott
Affiliation: University of Toronto
Keywords: Marine, geology, mineralogy, geochemistry, mining
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Steve Scott is a leading geochemist, mineral deposits geologist and, more recently, deep sea explorer. His early work on sphalerite established a geological pressure indicator which is used widely in ore deposits, metamorphic rocks and meteorites. His studies of ancient Cu-Zn deposits in Canada and more recent ones in Japan brought us a clearer understanding of their environment of deposition, particularly from the sediments around them, and prepared him for his present fascinating and most important work diving and sampling actively forming mineral deposits along the ridges of the oceans around North America.
Dr. Charles Scriver
Affiliation: McGill University
Keywords: Human biochemical genetics, human genomic variation, mutation databases, human population genetics
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Dr. Scriver's basic work concerned the expression of genes in the transport of amino acids across membranes of kidney cells and his concept of "inborn errors of transport'' and studies of gene dependent-abnormal vitamin dependencies. Two inborn errors of transport were discovered and ten new inherited biochemical diseases and some modes of treatment. He has received international recognition for applying genetic knowledge to the management of hereditary disease. He achieved a change in Quebec legislation so that vitamin-D is added to milk benefitting about 500 infants yearly. He pioneered the unique Quebec Genetics Network which screens virtually every new-born baby for hereditary metabolic diseases bringing treatment where needed. He lectures at McGill University and publishes extensively.
Geoffrey Scudder
Affiliation: The University of British Columbia
Keywords: Biodiversity, conservation, biosystematics, entomology
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Geoffrey Scudder is the world's authority on the lygaeid bugs, a family of insects that includes some of the world's most damaging agricultural pests. He has studied these insects in all the major museums, and has himself collected them on four continents. This work in systematics and distribution is only part of the much broader interest in the mechanism of organic evolution, where his studies include the adaptive mechanism of corixid bugs living in saline lakes, the functional morphology of the flight muscles, and the evolutionary significance of cardiac glycosides - brightly coloured poisonous compounds which some bugs sequester from plants and use as warning colours. Professor Scudder is recognized as an outstanding and knowledgeable teacher both in the University and community; he is one of Canada's most dedicated and productive zoologists.
Dr. Philip Seeman
Affiliation: University of Toronto
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Dr. Seeman has made fundamental contributions to the understanding of drug actions in the brain. His research on "fluidization" of cell membrane lipids provided an explanation of the anaesthetic action of drugs of widely differing chemical structure, and was the basis for a current theory of tolerance to such drugs. In 1974 he devised a method for measuring the numbers and binding properties of dopamine receptors in different parts of the brain. This internationally acclaimed work has led to the identification of different types of dopamine receptors and their roles in the pathophysiology and treatment of schizophrenia, Parkinson's disease and other diseases of the nervous system.
Dr. Alec Sehon
Affiliation: University of Manitoba
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Dr. Sehon first made his reputation in the field of bond dissociation energies and soon established an international reputation as an imaginative scientist, with some 20 papers published in this field. In the last 12 years he has brought powerful physico-chemical tools to bear on the problems associated with immunochemistry and allergens. His 75 papers in this field have brought international acclaim to his laboratory. With tremendous energy he almost uniquely combines the talents of the physical scientist with those of the biological, and this has brought him to the forefront of his profession.
Dr. Nabil Seidah
Affiliation: Université de Montréal
Keywords: Enzymology, molecular biology, protein analysis, neuroendocrinology, gene structure
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Dr. Nabil Seidah was trained at Georgetown University in physical chemistry before joining the Institute first as as post-doctoral fellow and then as director of the laboratory on biochemical neuroendocrinology. Dr. Seidah is the co-discoverer of human beta-endorphin and has worked on its biosynthesis for four to five years demonstrating in particular the exact sites of cleavage during pulse-chase experiments. For this work, he received the Clarke Institute Award in 1978 (Toronto). He was the first to develop, in collaboration with the late Margaret Dayhoff, (in the mid 1970's) computer programs to identify protein fragments from data of partial sequence at 10-15 M range. Since 1979, he has tackled one of the most crucial and central aspects of brain chemistry which is the characterization of the enzymatic systems for the cleavage of precursors at pairs of basic amino acid residues. Only a few scientists have had the courage and the determination to tackle this complicated problem. He, Donald Steiner, Peng Loh and J. Thorner are the main leaders in the field. Even though the international competition was very high, Dr. Seidah is the first to have identified a new family of enzymes by reverse genetics which has all the properties of the cleavage enzyme.
Dr. Seidah is a superb protein biochemist and he has added molecular biology to his wide expertise by spending one year sabbatical at the Pasteur Institute in Paris in 1987. He is now working on the protein aspect of his discovery and he is superbly prepared to bring it to fruition. Dr. Seidah is a chemist who has become an excellent biochemist and a world leader in his field. The new enzymes he discovered, called convertases, are at the crossroads of the new chemistry of the brain i.e. the neuropeptides. The cleavage of their precursors is a universal phenomenon which helps the brain to produce the tens of thousands of molecules it needs to insure his numerous and varied functions.
Dr. Bruce Sells
Affiliation: University of Guelph
Keywords: Science policy
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Professor Sells has made major contributions in the field of nucleic acid and protein synthesis and has greatly advanced our understanding of the assembly of ribosome particles in the living cell. The scientific excellence of Dr. Sell's research has been recognized by substantial research grants from Canadian and United States sources. He is author of 68 scientific publications, written several invited articles, and participated in International Symposia. His contributions have been recognized by the award of several fellowships and prizes. Dr. Sells is a member of numerous scientific societies and he has served the University and scientific community in various capacities. He was President of the Canadian Biochemical Society for 1981-82; a member of the National Cancer Institute of Canada on the grants panel, and a member of MRC. Professor Sells is currently Associate Dean of Basic Medical Research, Health Sciences.
Dr. Barry Sessle
Affiliation: University of Toronto
Keywords: Pain, neuroscience, motor control
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BARRY JOHN SESSLE, Professor, Faculty of Dentistry and Department of Physiology, Faculty of Medicine, University of Toronto, has provided major insights into neural mechanisms underlying orofacial function and into the aetiology and treatment of several disorders of the face, mouth and jaws related to pain, chewing and swallowing. His extensive and pioneering studies have resulted in remarkable advances in knowledge of the central neural organization of the trigeminal system, specifically of the brainstem mechanisms involved in orofacial nociceptive transmission and its control and neuroplasticity, the brainstem pathways underlying orofacial motor behaviours such as chewing and swallowing, and the organization and role of the sensorimotor cerebral cortex in the initiation and regulation of these motor behaviours.
Dr. George Setterfield
Affiliation: Carleton University
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Dr. George Setterfield's contribution to scholarship in cell biology during the past 20 years is equal to the best in this country. His research interests are wide, and his work is highly respected for its penetration of important questions and for its rigorous standards. Nothing in his published work is trivial.
His earlier research contributions include an elegant series of investigations on the fine structure and growth or plant cell walls. During the past 10 years, he and his graduate students have contributed much to the present understanding of the regulation of growth and reproduction of plant cells. His interest in regulatory phenomena have led also to recent productive studies of the role of chromosomal proteins in controlling structure and physiological activity of chromatin.
Dr. Setterfield is a distinguished teacher. He stimulates and informs students at all levels - from those of the general public who are casually interested in science and its implications for society, to those interested specifically in the intricacies of the plant cell. His former graduate students now occupy positions on university faculties and in government laboratories, from the prairies to Newfoundland.
Dr. Lotfollah Shafai
Affiliation: University of Manitoba
Keywords: Applied electromagnetics, radiating systems, antennas, microwaves, numerical computation
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Lotfollah Shafai, Professor, Department of Electrical and Computer Engineering, University of Manitoba, has contributed significantly in two areas of Applied Electromagnetics and Radiating systems. He has developed a generalized transformation method that relates the geometry and material property of objects to their electromagnetic field. He has pioneered the special decomposition technique that is used widely for computation of large structure scattering. He has also developed numerous efficient computational algorithms for complex problems in corona remote sensing and layer media. In the area of radiating systems he has pioneered the development of high performance and miniaturized reflector antennas, has pioneered wideband conformal sensors and antennas and developed award winning CAD tools for modelling and design of both. He has also contributed significantly to the development of low loss arrays at extremely high frequencies and millimeter waves.
Dr. Denis Shaw
Affiliation: McMaster University
Keywords: Trace elements
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The career of Denis Martin Shaw started in Lancashire and has led through an English lower school education and Cambridge University, followed by service in the Royal Air Force, graduate work and a doctorate at the University of Chicago, to an associate professorship at McMaster University. His researches have largely been an application of chemistry to geological materials and problems. That he has wondered a little about his field is perhaps indicated in the title of one of his papers, "The Nature and Some Results of Geochemistry." His special interest has been the behaviour in geological environments of certain rare elements, thallium, indium, gallium, lithium, and barium, and what happens to trace elements in rocks that have undergone progressive metamorphism. He has turned his attention to radioactive mineral deposits and throughout his bibliography a concern with techniques of spectrochemistry is evident. To provide some comfort for classical geologists, he has included the areal geology of part of Calumet Island. In academic circles, Dr. Shaw has proved his ability as a successful teacher and administrator.