"In recognition of his broad, pioneering fundamental and applied contributions to chemical thermodynamics which have resulted in the development of databases, computational procedures for phase diagrams and equilibria in multicomponent solutions and the world's most powerful user-friendly system (F*A*C*T) to tackle thermochemical problems In far flung fields ranging from geology to materials science and petrochemistry".

Dr. A.S. Perlin is known nationally and internationally for his work on carbohydrate chemistry. Initially he was interested in the chemistry of plant gums and mucilages, later he turned his attention to the use of lead tetraacetate in the determination of the structure and identification of the glycosidic linkages of carbohydrates. This procedure, which has been used by many workers, supplements evidence obtained by use of enzymes. In recent years, his major interests have been concerned with applications of nuclear magnetic resonance spectroscopy, as well as with chemical synthesis. The properties and reactions of simple sugars to the characterization of such large molecules as heparin action of carbohydrate-modifying enzymes. His career at McGill follows 20 years with the National Research Council of Canada.

Dr. M. B. Perry has established an outstanding record of research in carbohydrate chemistry. His major contributions have been structural studies of microbial polysaccharides and the development of the analytical and synthetic methods that were necessary for the success of those studies. He was among the first to work out biosynthetic pathways of some unusual sugars found in bacterial polysaccharides and was the first to prove, by isolation, analysis and synthesis, the presence of 3-deoxyD-manno-octulosonic acid (KDO) as a key component of lipopolysaccharides. His recent and extensive work on 'Neisseria gonorrhoeae' has established Dr. Perry as a world authority on the immunology and immunochemistry of this important species.

Howard E. Petch, Director of Research, McMaster University, founded a laboratory in solid state physics at McMaster University in 1954, and a Department of Metallurgy at the same university in 1957. Since then, he has vigorously attacked a variety of crystals. With increasingly versatile armaments at his disposal, such as nuclear magnetic resonance, X-ray diffraction, electron-spin resonance, and neutron diffraction, he has contributed greatly to our knowledge of crystal structure. The number and quality of his published papers, the enthusiasm and accomplishments of his students and colleagues, and his recent appointment as Director of Research at McMaster, all attest to his research spirit and achievement.

ERNEST PETERS, Professor of Hydrometallurgy, Department of Metals and Materials Engineering, University of British Columbia, has made outstanding contributions in the application of fundamental sciences (thermodynamics, kinetics, solution chemistry, precipitation chemistry and electrochemistry) to hydrometallurgy processes.

Dr. A.G. Phillips has made major contributions to behavioral neurobiology and, in particular, to understanding the neural mechanisms of learning and memory and of motivation. Using neurotoxins to damage dopamine neurons and antagonist drugs to block them, Dr. Phillips has shown that brain dopamine has a major role in mediating reward and in the acquisition of new patterns of motor activity as well as the initiation of species-specific adaptive behaviors. His findings are relevant in elucidating the mechanisms of drug addiction and the therapeutic effects of antipsychotic drugs. Dr. Phillips' research achievements have been recognized by awards of the E.W.R. Steacie Fellowship (NSERC) and of a Killam Senior Research Scholarship (Canada Council).

Dr. George Pickard is one of the pioneers in the teaching of physical oceanography in Canada. As a professor of physics in the Department of Physics at the University of British Columbia, and the Director (since 1958) of the Institute of Oceanography, he has introduced many students into the problems of the ocean and has directed their research. He has published widely in the oceanographic field since 1951, his particular specialty concerned with the oceanographic problems of British Columbia inlets. As a member of the Canadian Committee on Oceanography and the Fisheries Research Board of Canada, he plays an active role in coordinating oceanographic research in Canada.

Edward Piers has made notable contributions to the field of synthetic organic chemistry, both with respect to the synthesis of naturally occurring compounds and to the development of new synthetic methods. His research group has completed an impressive number of total syntheses, including the first preparations of aristolene, copaborneol, seychellene, and eshwarone. These syntheses have become classic examples of the elegant use of logic in the synthesis of natural products, particularly with regard to control of stereochemistry. He has also added a number of extremely useful general synthetic methods to the organic chemist's armoury.

Using the analytical mind of a physicist, Dr. Platt has brought to biological oceanography new concepts in quantitative ecology. He has developed mathematical descriptions of photosynthesis, statistical studies on the representativeness of samples, a theory on size structure of pelagic populations, reanalysed data on the global oxygen and C02 fluxes in the ocean and worked on the nature of the submarine light field in the context of remote sensing. His theoretical and practical work has been applied to practical problems such as determining the absolute yield of renewable resources from the sea and to the problem of atmospheric CO2 accumulation. He is active on many international committees and has received 5 medals for his distinguished contributions to oceanography.

Dr. Barry Posner has published some 290 papers and has established a national and international reputation for his research on receptors and growth factors especially the regulation and functions of the insulin receptor kinase (IRK). His first contribution was the finding of insulin receptors in "nontarget" tissues such as placenta which led to a new and more general way of defining hormone target tissues. In demonstrating that prolactin induces its own receptor he was one of the first to show regulation of receptor by ligand. Subsequently he found that ligands both up-and down-regulate their receptors depending on ligand concentration and duration of exposure. He showed that polypeptide hormone receptors were enriched in Golgi elements consistent with their role as precursors for the plasma membrane receptors. He went on to demonstrate internalization of ligand-receptor complexes to structures which he and his colleagues named endosomes and showed that such complexes were involved in signal transduction within the cell. Thus the paradigm that signaling occurred exclusively at the cell surface was changed to include a substantial other cellular compartment - the endosomal system. He and his colleagues discovered that insulin clearance began in endosomes by the action of an insulin specific protease, the physiological enzyme for degrading cellular insulin. In addition he demonstrated the existence of an IRK-associated phosphotyrosine phosphatase (PTP) a key regulator of IRK function. Using peroxovanadium agents he and his colleagues showed that inhibiting this PTP provoked IRK-mediated insulin signaling in the complete absence of insulin. This established the basis for the development of a new class of insulin mimickers which might eventually replace insulin in the treatment of Diabetes. Finally he has studied insulin -like growth factors and found that they may negatively feed-back on pituitary growth hormone secretion; and has demonstrated that peptide hormone receptors are in brain, particularly in the circumventricular organs through which they transmit centripetal signals to deeper neuronal structures.