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Dr. Naranjan Dhalla
Affiliation: University of Manitoba
Keywords: Heart failure, Ischemic heart disease, diabetic cardiomyopathy, cardiac hypertrophy, stress-induced heart disease.
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Naranjan S. Dhalla is known for his pioneer work on the pathophysiology of heart disease in general and subcellular defects leading to the development of cardiac contractile failure in particular. His research has shown that membrane abnormalities depend upon the type and stage of heart disease. Extensive work from his laboratory regarding remodelling of subcellular organelles in congestive heart failure as well as heart dysfunction in chronic diabetes now forms the basis for newer therapeutic strategies. He also demonstrated that stress-induced coronary spasm, arrhythmia, contractile failure and cell damage are due to the formation of oxidation products of catecholamines.
Dr. Sergio Grinstein
Affiliation: University of Toronto
Keywords: Ion transport, pH regulation, signal transduction, leukocyte biology, phagocytosis
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Sergio Grinstein's is an expert on ion transporters and their roles in intracellular homeostasis, namely, the control of cell volume and of intra-cellular and intraorganelle parameters such as pH and calcium concentration. He has devised methods for the measurement of pH in individual subcellular compartments within living cells. These and other remarkable methods have been widely used by his group and by others to study intracellular homeostasis. He has also made important contributions to the understanding of how white blood cells are activated to destroy microbial invaders. Dr. Grinstein has published over 280 papers since 1974 as well as many book chapters and reviews. He has given numerous invited lectures at international conferences and is recognized by his peers as an international authority in his field.
Dr. Nigel Higson
Affiliation: The Pennsylvania State University
Keywords: Operator algebras, K-theory, functional analysis, index theory, geometric analysis.
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Nigel Higson, Department of Mathematics, The Pennsylvania State University, is a leader in the field of operator algebras in Hilbert space, together with its applications to geometry, topology, and the representation theory of groups. He has made definitive contributions towards the solution of deep conjectures due to Novikov, and to Baum and Connes. His work will have lasting influence.
Dr. Amira Klip
Affiliation: University of Toronto
Keywords: Insulin action, intracellular signalling, muscle cell physiology, glucose uptake, intracellular traffic
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Amira Klip pioneered critical studies of glucose and ion transport, key biological phenomena. Using cellular and molecular tools, she was the first to observe that insulin and exercise cause translocation of glucose transporters (GLUT) and Na/K-pumps to the surface of rodent and human muscle. She introduced muscle cell lines to study anti- diabetic drug action. She discovered: the participation of the enzyme Akt and the cytoskeleton in GLUT translocation; the key proteins involved in GLUT fusion with the cell surface; a bimodal regulation of GLUT biosynthesis by insulin and glucose. These discoveries have had major impact in the field of diabetes research.
Dr. Bryan Kolb
Affiliation: University of Lethbridge
Keywords: Brain plasticity, neuroscience, neuropsychology, cerebral cortex, brain developer
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Bryan Kolb has achieved distinction by publishing both learned works and original research in the field of neuropsychology. Among his scientific findings are that considerable recovery of function is possible following brain damage at certain ages, that recovery involves anatomical sprouting allowing for new connections by surviving neurons, and that under some circumstances new cells are born that replace those damaged by injury to the post-natal mammalian forebrain. His studies have involved both laboratory animals and human patients. With lan Whishaw, he has written the leading textbook in human neuropsychology, now in its fourth edition, published in three languages.
Dr. Jerald Lawless
Affiliation: University of Waterloo
Keywords: Survival analysis, reliability, event history analysis, biostatistics, stochastic models.
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Jerald Franklin Lawless has made major and deep contributions to the theory and practice of statistics. He is internationally recognized, in both academia and industry, as one of the pre-eminent researchers in the field of reliability and survival analysis where he has identified and pioneered investigation in several important areas. He has also made many outstanding contributions to general statistical theory and methods. He has published many research articles in the strongest journals, books and conferences in his discipline and has authored a highly influential book on reliability. He also holds the NSERC/General Motors Industrial Research Chair in Quality and Productivity at the University of Waterloo.
John Lee
Affiliation: McGill University
Keywords: Detonation waves, shock waves, combustion, explosions, fluid mechanics
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John Lee is internationally recognized for his scientific expertise in the field of combustion and shock wave physics. He has made significant fundamental contributions to the understanding of the detonation and deflagration phenomena leading to the development of quantitative theories of practical significance. He has received numerous awards in recognition of his scientific work and also his outstanding teaching.
Dr. John McKay
Affiliation: Concordia University
Keywords: Algebra, finite simple groups, computational algebra, representation theory, monstrous moonshine
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John McKay pioneered the field of computational group theory, especially the construction of characters and new simple groups. He discovered deep connections between group structures that have driven fundamental developments in finite groups over the past three decades, such as the "Alperin-McKay conjecture", relating irreducible characters of groups and their local subgroups. His discovery of the "McKay-Thompson series", relating expansions of modular functions to the characters of the "Monster" sporadic group, led to the "Moonshine" conjectures, proved recently by Borcherds. He also discovered a deep relationship between certain finite groups and associated Lie algebras, known as the "McKay correspondence", which has had many recent applications in mathematics and physics.
Dr. Alexander McLean
Affiliation: University of Toronto
Keywords: Thermodynamics, inclusions, sensors, casting, steelmaking
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Professor McLean is recognized worldwide as Canada's most distinguished scientist in the field of physical chemistry of steelmaking. His philosophy has been to develop fundamental understanding of scientific phenomena and facilitate implementation of the acquired knowledge within production systems. Professor McLean's pioneering work on reoxidation reactions involving thermodynamics, kinetics and fluid flow studies has revolutionized industrial practice for the continuous casting of steel and led to levels of quality which would not have been otherwise attainable. Additional contributions have included the chemistry of oxide melts; plasma processing; sensor development and the net-shape casting of novel materials. He has authored over two hundred technical papers and six books. The numerous honours and awards which he has received from academic institutions and professional societies within Europe, Japan and North America, are clear evidence of the high regard in which Professor McLean is held by the international metallurgical community.
Dr. John McNeill
Affiliation: The University of British Columbia
Keywords: Diabetes, hypertension, cardiomyopathy, vanadium, insulin resistance
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John McNeill has made important contributions to several areas of pharmacological research. During the past decade, he has concentrated on the effects of diabetes on the heart. His laboratory has been able to demonstrate pathological changes in hearts of diabetic animals, which resemble the cardiomyopathies seen in human diabetics. They have made the important discovery that oral administration of vanadium salts can lower blood sugar and prevent the secondary complications of diabetes in these animals. This observation has opened up a whole new area of investigation. Dr. McNeill and his group are currently studying several synthetic vanadium compounds which have the potential to be useful therapeutic agents. It is possible that oral administration of these agents will be able to substitute for insulin injections in the treatment of diabetic patients.
Dr. Tofy Mussivand
Affiliation: University of Ottawa
Keywords: Medical engineer, biomedical engineering, telemedicine, medical devices, cardiovascular scientist, virtual patient simulator, artificial heart
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A scientific leader in medical engineering, research, development, and training, his Canadian Artificial Heart Program has already brought scientific recognition and eminence to Canada, with a device that could save thousands of lives. His innovative and visionary work includes advances in non-invasive powering of implanted devices, the reduction of blood clotting, and a revolutionary system for remote patient care and healthcare delivery. Another important undertaking is the Healthwatch, an innovative device for early stage disease detection and prevention. He is an inventor with several international patents and an effective educator having trained more than 200 students, post- doctoral fellows, and residents. He has authored over 200 journal articles, reports, abstracts, book chapters, and books. His scientific endeavors have led to significant funding for medical and clinical engineering research and the creation of over 300 man/years of employment. In summary, Dr. Mussivand is an outstanding scientist and educator, with persuasive talents and innovative vision.
Dr. Leo Renaud
Affiliation: University of Ottawa
Keywords: Neurotransmission, neuropeptides, hypothalamus, posterior pituitary, vasopressin
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Leo Renaud, a physician and neuroscientist, is recognized internationally for his pioneering efforts in defining a role for peptides in synaptic transmission in the mammalian central nervous system and for the identification and functional characterization of pathways in the brain that are critically involved in maintaining cardiovascular and hydromineral homeostasis. He has contributed substantially to the establishment of hospital-based centres for research and training both at McGill University and the University of Ottawa, and many of his own students are now established neuroscientists. In 1994, he received a prestigious Distinguished Scientist Award from the Medical Research Council.
Dr. John Ripmeester
Affiliation: National Research Council
Keywords: Nuclear magnetic resonance, guest-host chemistry, microporous solids, clathrates, inclusion compounds
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John Ripmeester is an internationally renowned physical chemist specializing in the applications of nuclear magnetic resonance (NMR) spectroscopy to the solid state. His pioneering and developmental work on the use of techniques in structural chemistry has provided a new window into guest-host compounds such as clathrates, inclusion compounds and zeolites which has led to detailed structural-dynamical models and a better understanding of a technologically important class of materials. He is a world-leading authority on the structure and physical chemistry of gas hydrates, having discovered new hydrate structures and pioneered instrumental methods of hydrate analysis. His groundbreaking exploratory work on the NMR spectroscopy of occluded xenon led to a new and now popular probe of pore spaces in solids.
Derek Roff
Affiliation: University of California
Keywords: Evolutionary biology, conservation, quantitative genetics
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Derek Roff is a leading evolutionary biologist who has made important experimental and theoretical contributions to two areas. The first is the evolution of life histories, which deals with patterns of growth, reproduction and survival in different environmental conditions. The second is evolutionary quantitative genetics, which describes how selection acting on traits determined by any genes modifies the genetic structure of populations. Besides publishing over a hundred papers in the primary literature, he has written two books on these topics that are the most comprehensive and up-to-date syntheses available. Finally, he has applied his mastery of these fields to a range of practical problems.
Dr. Allan Ronald
Affiliation: University of Manitoba
Keywords: Aids/HIV, clinical trials, epidemiology, antimicrobial resistance, infection pathogenesis
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Allan Ronald graduated from Manitoba, completed his Residency and Fellowship training in Internal Medicine, Microbiology and Infectious Diseases in the United States and returned to Winnipeg in 1968. During the past 29 years in Winnipeg, he has created one of the world's premier Infectious Disease groups. Over 70 scientists and skilled specialists have been trained and he has carried out research which has influenced the management of Infectious Diseases with almost 400 publications. Of note is the research program that he established in Nairobi, Kenya in 1980 which has solved many issues relating to the spread and control of HIV in resource-limited societies. He has also contributed administratively with 14 years as a Department Head and four years in Faculty administration. His contributions have been recognized by his successful nomination to the American Society for Clinical Investigation, the American Association of Physicians and his naming as an Officer of the Order of Canada in 1994. Currently he serves as President of the International Society of Infectious Diseases as well as on numerous international committees.
Dr. Gordon Semenoff
Affiliation: The University of British Columbia
Keywords: Elementary particles, quantized fields, superstrings, matrix models, mathematical physics
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Gordon Semenoff is a theoretical physicist who is well known for his fundamental ideas and pioneering work in quantum field theory, statistical mechanics and string theory. His studies include the formulation of quantum field theory in hot environments, pioneering work on the application of topology and geometry in physics, field theoretical models of particles with exotic statistics and non-trivial solutions of random matrix theories.
Dr. Gordon Slade
Affiliation: The University of British Columbia
Keywords: Critical phenomena, lace expansion, percolation, self-avoiding walk, super-brownian motion
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Gordon Slade is the world's leading expert in the use of the lace expansion. With Takashi Hara, he has used this technique to solve a series of difficult and important problems in statistical mechanics. He has proved "mean field" behaviour of the self-avoiding random walk above the critical dimension of 4, and of percolation in sufficiently high dimensions. Working with his student Eric Derbez, Slade has also connected two quite distinct areas of probability by proving that, above the critical dimension of 8, lattice trees converge to the integrated super-Brownian excursion.
Robert Wolkow
Affiliation: University of Alberta
Keywords: Scanning tunneling microscopy, silicon, surface science, nanotechnology, molecular devices
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Robert Wolkow has made seminal contributions to the field of scanning tunneling microscopy (STM). He performed the first atomic-scale study of a surface reaction, initiating a new field. He developed the first tunable temperature cryogenic STM and with it determined the structure of Si(l 00), solving a classic problem. He was first to capture the dynamics of silicon atoms settling in to epitaxial positions on a silicon surface. His direct observation of a precursor to chemical bond formation is a breakthrough. He has determined the absolute chirality of individual molecules. His work has substantially advanced the field of organic-silicon interfaces.
Dr. James Woodgett
Affiliation: University of Toronto
Keywords: Signal transduction, cell biology, neuroscience, cancer
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James Woodgett is Head of Experimental Therapeutics at the Ontario Cancer Institute and a major contributor to our understanding of the mechanisms by which proteins can convey signals and regulate cell activity. He began with studies of a protein regulator of glycogen metabolism (GSK-3); he showed that GSK is part of the signal pathway that is important in hepatic apoptosis. Woodgett's major work has been the elucidation of the signaling pathway triggered by genotypic stress. The Stress Activated Protein Kinase (SAPK) pathway is important in cellular response to drugs and may play a key role in resistance to cancer chemotherapy. His accomplishments have been recognized by appointment as Senior MRC Scientist, early promotion to full professor and appointment as Head of Experimental Therapeutics at the Ontario Cancer Institute.
Dr. Andrew Wiles
Affiliation: Princeton University
Keywords: Modular forms, galois representations, ecliptic curves, fermat, number theory
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Andrew Wiles, Department of Mathematics, Princeton University, has, through his insight and perseverance, made one of the most distinguished contributions to mathematics. In establishing the celebrated Taniyama-Shimura-Weil Conjecture, he, at one and the same time, put to rest Fermat's Last Theorem, unproved for almost four hundred years, and provided crucial verification—solving the one-dimensional case—of the so-called Langlands program—a remarkably far-reaching conjectural synthesis (by the Canadian mathematician Robert Langlands) of much of the mathematics of that four hundred years—much of which was brought into being by the riddle of Fermat.
Dr. Raymond Price
Affiliation: Queen's University
Keywords: Structural geology adn tectonics, science and public policy
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As a result of his investigations in the Rocky Mountains, Dr. Price has thrown considerable light on the complexitites of the region, integrating structural and physical theories in his interpretation of the nature of the deformation both on a small and grant scale. He has established principles and techniques applicable to the study of mesoscopic subfabrics in deformed unmetamorphosed strata and delineated fundamental geometric attributes of folds that are critical to a reconstitution of the mechanisms of folding. He has contributed new and important concepts to the establishment of a regional framework of the physical stratigraphy, particularly of the Proterozoic, Devonian and Mississippian sequesnces and the larger geological structures of northern Yukon and the southern Rocky Mountains. He has proposed a model relating spatially and temporally the metamorphic regimes of the Western Cordillera with the decollement thrust sheets of the Eastern Cordillera. Dr. Price was awarded the Gold Medal in Science from the Univeristy of Manitoba and the Higgins and Procter Fellowships from Princeton University.
David Bentley
Affiliation: Western University
Keywords: Poetry, editing, ecocriticism, architecture, Canada
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David M.R. Bentley, Department of English, The University of Western Ontario, is one of the foremost contributors to research in the field of pre-twentieth century Canadian literature, particularly in the area of the long poem. Bentley has also made enormous contributions to Canadian poetry through his dedicated work as an editor. He co-founded and edits Canadian Poetry: Studies, Documents, Reviews. His Mimic Fires: Accounts of Early Long Poems on Canada and his anthology of Early Long Poems on Canada marked a milestone in Canadian letters. His scholarship is admirable for its quality, its completeness, and its balance.
Dr. R. Gordon Moyles
Affiliation: University of Alberta
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A broadly humanistic scholar, Dr. Gordon Moyles has written prolifically and trenchantly on Canadian history, law, and culture. He is also in the front rank of textual scholars, applying his expertise not only to the textual history, emendation and editing of John Milton's Paradise Lost but to the major scholarly edition of the poems of E.J. Pratt. In addition, he has done ground-breaking bibliographical research in Canadian literature and history. In spite of the technical erudition of much of his work, he writes with a verve that appeals to a wide range of general readers.
Dr. Wallace Lambert
Affiliation: McGill University
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The name Wallace E. Lambert is synonymous with the development of psycholinguistic and sociolinguistic research interests and techniques in North America. He has focussed his attention on the topics of bilingualism and biculturalism at a time when an unbiased scientific approach to socially relevant problems was often lacking.
Among active social scientists, he almost uniquely, has managed to bridge the gap between theory and application. His ideas and research findings, from this Canadian setting, have encouraged educators in many parts of North America to radically redesign their foreign language teaching programs while at the same time generating research from all over the world to examine the adequacy of his social psychological theories of language acquisition.
His recent election as President of the Canadian Psychological Association reflects both his qualities of leadership and the high esteem with which he is regarded by his peers.