Dr. Zamponi is one the world's leading researchers on the molecular neurophysiology of ion channels. His seminal research programs have resulted in numerous contributions to both the basic and biomedical fields. The work has variously described the underlying mechanisms of calcium channel function and modulation by a variety of intracellular signaling molecules and pathways. Other contributions include defining the physiological consequences of genetic defects associated with calcium channel dysfunction in generalized epilepsies and congenital night blindness. The work has also defined novel molecular mechanisms responsible for signaling complexes crucial to pain signaling and relevant to human neuropathic pain conditions.