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Dr. Peter Macklem
Affiliation: McGill University
Keywords: Mechanics of breathing, thermodynamics of living organisms
Deceased Date: 2011-02-11
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There is virtually no aspect of respiratory mechanics to which Dr. Macklem has not made a fundamental contribution. Of particular importance is his work on airways dynamics and small airways disease. Indeed, the very concept of 'disease of the small airways' stems from the logical sequence of his systematic investigations. In addition, he has pioneered the notion that the inspiratory muscles may fail in much the same manner as the myocardium. This has led to an expolsion of interest into an important but previously neglected area of respiratoy physiopathology. Dr. Macklem's work has been most influential not only in Canada but throughout the world.
Dr. Charles Macklin
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Dr. D. MacLean
Affiliation: McMaster University
Deceased Date: 2003-08-19
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Dr. David MacLean is one of Canada's leading chemists in the field of natural products. His studies, in the 1950's, on the structure of annotinine set the stage for an intensive program of research on the lycopodium alkaloids in a number of laboratories, of which his own has continued to be in the forefront. Recognizing the potential of the mass spectrometer in the elucidation of chemical structure, he pioneered in its use in Canada and he is recognized as an important contributor to the field. For the past five years, he has been an effective leader as Chairman of the Department of Chemistry.
Dr. Lloyd MacLean
Affiliation: McGill University
Deceased Date: 2015-01-14
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This surgeon has consistently applied physiological principles and advances in basic science to the needs of surgical patients. Most notable have been the investigations in shock and in organ transplantation. In the studies on shock he established the hemodynamic characteristics of septic or endotoxin shock in experimental animals. Hemodynamic findings in a large group of patients with all forms of shcok have been reported. These have led to the recognition of the importance of basing treatment on these measurements at the bedside, in many centers throughout the world, and by the surgical teams in Viet Nam. The studies on cellular problems of septic shock have led to development of new techniques and concepts which assist greatly in patient care.
His work in transplantation concerns basic principles of organ preservation, mechanisms of rejection, prediction of ideal transplant partners, and a careful system of follow-up of transplanted patients to guide further treatment and policies in this rapidly changing field.
MacLean has been the guest speaker on these two general topics at many international symposia in Europe, America and South Africa. He has been heavily involved in undergraduate and graduate teaching, and in the administration of a research facility grant support of which has grown from $50,000 per annum to $500,000 per anum over the past seven years.
Dr. David MacLennan
Affiliation: University of Toronto
Keywords: Calcium pump, calcium release channel, phospholamban, malignant hyperthermia, cardiomyopathy
Deceased Date: 2020-06-24
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Dr. MacLennan is internationally known for his work on isolation and characterization of proteins of the sarcoplasmic reticulum. His laboratory has cloned DNA encoding many of these proteins and used heterologous expression and site-directed mutagenesis to understand structure- function relationships in such key transport proteins as the Ca2+ pump, the Ca2+ release channel, modulatory proteins such as phospholamban and sarcolipin and Ca2+ binding proteins such as calsequestrin, calreticulin and sarcalumenin. His work has contributed greatly to our present knowledge of the mechanism of cation transport across biological membranes. He has demonstrated the genetic basis for inherited muscle diseases resulting from defects in Ca2+regulatory proteins and he has contributed to diagnosis and understanding of the pathophysiology of these human diseases. He has also contributed to agriculture through development of a diagnostic test for porcine stress syndrome, leading to its elimination from herds worldwide.
Dr. John Hugh MacLennan
Deceased Date: 1990-11-07
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Dr. Robert MacLeod
Affiliation: McGill University
Deceased Date: 2013-05-06
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Bob MacLeod, originally trained as a chemist at U.B.C. worked under the direction of Prof. E. Snell at the University of Wisconsin on metal ion nutrution. He has continued his research in this area studying intensively the requirements for certain metal ions on a marine bacterium. His elegant techniques and deep insight into the role of cell walls and cellular membranes in transport mechanisms have given him international fame. He is in constant demand to present his research orally and in chapters for spcecialty textbooks. He has been able to assemble a very active group of graduate students and post-doctoral fellows that has become on of the most prolific and best known in Canada. Dr. MacLeod received the Harrison Prize from the Royal Society of Canada in 1960. He is an active member of various societies especially the Canadian Society of Microbiologists whom he has served in many capacities and the Canadian Journal of Microbiology having served as both Associate and Assistant Editor. He is Professor in the Department of Microbiology, Faculty of Agriculture, at McGill University.
Dr. John James Rickard Macleod
Deceased Date: 1935-03-16
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Alistair MacLeod
Affiliation: University of Windsor
Deceased Date: 2014-04-20
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Alistair MacLeod is one of the foremost writers, scholars and teachers in the field of Canadian literature. His contribution both to creative writing and to literary scholarship is immense. He is a brilliant and evocative writer, whose stories of Maritime Life intensely enact the perils and passions of a whole way of life. His writings, particularly his short stories, have been translated into thirteen (13) languages. Praise for his work has come from every corner of Canada and from other parts of the world: he has been characterized as "one of North America's masters of the short story" as well as "a truly great writer." Reflecting on MacLeod's work, the late Hugh MacLennan stated: "This may well be the best pure writing ever to appear in Canadian Fiction."
Dr. Millar MacLure
Deceased Date: 1990-11-06
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Dr. Archibald MacMechan
Deceased Date: 1933-08-07
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Dr. Gordon MacNabb
Affiliation: None
Keywords: Research management
Deceased Date: 2020-03-15
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An inspiring leader with a vision of Canadian Research in Science and Engineering, Gordon MacNabb set the foundations of NSERC which sustain it to this day. He was, and continues to be, a tireless champion of science and engineering in Canada, a role which he brilliantly fulfilled as President of NSERC and founder of PRECARN Associates. He continues as a source of wisdom in the development and application of the Canadian Human Resource for the benefit of our country. He has made a significant mark on Canadian society and on the Canadian scientific and engineering community in particular.
Dr. John MacNamara
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Dr. John MacNaughton
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Dr. Donald MacNeil
Deceased Date: 1968-11-21
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Dr. William MacNutt
Deceased Date: 1976-02-09
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Dr. John Macoun
Deceased Date: 1920-07-18
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Dr. Moray Macphail
Affiliation: Carleton University
Deceased Date: 2013-08-12
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Sir Andrew Macphail
Deceased Date: 1938-09-23
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Dr. Crawford Macpherson
Deceased Date: 1987-07-21
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Dr. Donald MacRae
Affiliation: University of Toronto
Deceased Date: 2006-12-06
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MacRae's early research in galactic structure, stellar photometry and spectra, and stellar statistics constituted a significant contribution to our knowldege of the detailed structure of the galaxy and interstellar material. Since returning to the University of Toronto in 1953 he has vigorously supported the research programs of the David Dunlap Observatory and has shown an outstanding degree of versatility in initiating new research programs. Among these were: (a) the setting up of a technique of precision photometry for the determination of the apparent magnitudes of over 1000 stars of a large radial-velocity program, (b) pioneer work in the use of an electronic computer for the solution of spectrographic binary orbits, (c) the design, construction and use (in collaboration with Oke) of a photoelectric spectrophotometer for the 74-inch telescopean instrument which is the prototype of similar instruments now used elsewhere, (d) the organization and leadership of a radio astronomy project, operated with continuing and increasing government support, jointly by the Departments of Astronomy and of Electrical Engineering at the University of Toronto. This radio astronomy project has served the IGY in the study of solar radio radiation as well as the IAU and URSI in the measurement of absolute flux from discrete sources, and it is an important centre of research training for radio astonomers and a source and testing ground of new ideas for the new Canadian radio observations at White Lake, B.C. (Dominion Observatories) and at Algonquin Park (N.R.C.).
Neil Madsen
Affiliation: University of Alberta
Keywords: Biochemistry, biography, history
Deceased Date: 2017-03-22
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Neil B. Madsen has made numerous contributions to the field of enzymology. HIs early studies of phosphorylase led to the first demonstration of sub-unit structure of an enzyme, and to the development of the concept of allosteric enzymes. Subsequently he contributed to the discovery of the glyoxylate cycle, and discovered the phenomenon of feed-back control of glycogen metabolism. His more recent studies have provided insight into the molecular mechanisms of the control of glycogen metabolism, have made possible the determination of the structure of phosphorylase at atomic resolution, and are well on their way to explaining the mechanisms of its catalytic function and allosteric properties. He is the author of 103 publications, has served as President of the Canadian Biochemical Soceity (1970-71), Chairman of the Science Policy Committee of the Canadian Federation of Biological Societies (1973-75), and Chairman of the latter organization (1977-78).
Mr. Charles-Joseph Magnan
Deceased Date: 1942-06-02
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Dr. Charles Magrath
Deceased Date: 1949-10-30
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