Long Citation Lewis Kay is internationally recognized as a leader in the development and application of nuclear magnetic resonance (NMR) spectroscopic methods for the study of protein structure and dynamics. He has pioneered novel approaches for the study of protein dynamics, developed new isotope labelling methods to facilitate structural studies of large biological complexes, and used innovative methods to examine membrane proteins. His work, published in over 250 papers, has provided insight into the action of many important biological molecules. Dr. Kay is a superb mentor, a generous collaborator and a model citizen of the scientific community. Short Citation Lewis Kay is internationally recognized as a leader in the development and application of NMR spectroscopic methods for the study of protein structure and dynamics. He has pioneered novel approaches for the study of protein dynamics, developed new isotope labelling methods and used innovative methods to examine membrane proteins. Dr. Kay is a superb mentor, a generous collaborator and a model citizen of the scientific community.

Long Citation Sarah Otto is the foremost theoretical evolutionary biologist in Canada and one of the most respected in the world. Her research on the evolutionary forces that act on the structure of the genome has revealed novel and surprising insight into such fundamental aspects of an organism as the number of chromosomes present, sex and recombination rates along these chromosomes, and the nature of interactions among genes. Her research has demonstrated how these evolutionary forces depend on aspects of a species and its environment, helping to explain the remarkable diversity of life at the genomic level. Short Citation Sarah Otto is the foremost theoretical evolutionary biologist in Canada and one of the most respected in the world. Her research on the evolutionary forces that act on the structure of the genome has revealed novel and surprising insight into such fundamental aspects of an organism as the number of chromosomes present, sex and recombination rates along these chromosomes, and the nature of interactions among genes.

Long Citation Francis Plummer is a physician-scientist, with an eclectic interest in the study of human infections. He is best known for work on AIDS. His studies of HIV-1 in Africa led to the identification of mechanisms of heterosexual transmission of HIV-1 and ultimately the development of highly effective interventions, which are in use world-wide in combating HIV-1. His current work focuses on mechanisms of natural protective immunity in a group of HIV-1 resistant prostitutes in Kenya. This now classic work has helped to rejuvenate and guide HIV-1 vaccine research. He has authored more than 250 research articles and reviews. Short Citation Francis Plummer is a physician-scientist, with an eclectic interest in the study of human infections. His studies of HIV-1 in Africa led to the identification of mechanisms of heterosexual transmission of HIV-1 and ultimately the development of highly effective interventions, which are in use world-wide in combating HIV-1. His work on mechanisms of natural protective immunity in a group of HIV-1 resistant prostitutes in Kenya has helped guide HIV-1 vaccine research.

Long Citation Dr. Michael Rudnicki is an outstanding young scientist whose studies of muscle development have placed him at the forefront of international science. He has discovered the key molecules that regulate muscle development in the embryo and that control muscle regeneration from stem cells following injury. For close to 15 years, Dr. Rudnicki's research has consistently broken new ground and challenged existing paradigms resulting in entirely new concepts of muscle development. His research clearly delineates the importance of stem cells in the regenerative process and paves the way for new therapeutic approaches to a cure for muscular dystrophy and the 40 other neuromuscular disorders. As an internationally renowned scientist, a mentor to a large group of young researchers, a highly effective leader in his own institution and as a scientific opinion leader, Dr. Rudnicki's election to the Royal Society of Canada will bring credit to the Society. Short Citation Michael Rudnicki is an outstanding young scientist whose studies of muscle development have placed him at the forefront of international science. He has discovered the key molecules that regulate muscle development in the embryo and that control muscle regeneration from stem cells following injury. Dr. Rudnicki's research has consistently broken new ground and challenged existing paradigms resulting in entirely new concepts of muscle development.

Long Citation Ernesto Schiffrin is one of the great clinical scientists in Canada, and a world leader in the field of the mechanisms and management of arterial hypertension. Amongst many contributions, he demonstrated that anti-hypertensive drugs interfering with the renin-angiotensin-aldosterone system correct blood pressure and the structural remodeling of resistance arterioles, and he showed the role of endothelin in this vascular remodeling. Dr. Schiffrin brings together a profound knowledge of molecular and clinical medicine. His fundamental work has been recognized amongst many honours by his election as President of the American Heart Association Council for High Blood Pressure Research. Short Citation Ernesto Schiffrin is one of the great clinical scientists in Canada, and a world leader in the field of the mechanisms and management of arterial hypertension. Amongst many contributions, he demonstrated that anti-hypertensive drugs interfering with the renin-angiotensin-aldosterone system correct blood pressure and the structural remodeling of resistance arterioles. He also showed the role of endothelin in this vascular remodeling.

Notice longue Le professeur Michel L. Tremblay est un expert mondial des protéines tyrosines phosphatases ( les PTP). Ses travaux remarquables sur cette importante classe d’enzymes en ont démontré le rôle dans une grand nombre de fonctions essentielles à la vie. Il a réalisé ces découvertes majeures par l’utilisation avant-gardiste des souris transgéniques afin d’étudier leurs fonctions. Dans son article majeur sur l’inactivation du PTP-lB, publié dans Science, il a démontré qu’elle jouait un rôle important dans la progression du diabète, de l’obésité et récemment dans le cancer. Plus de 40 sociétés pharmaceutiques dans le monde entier ont maintenant un programme de recherche sur les médicaments à base de PTP-lB, ce qui illustre de façon éloquente l’impact de ces recherches sur la santé humaine. Michel L. Tremblay a élargi cette approche fructueuse à d’autres membres de la famille des protéines tyrosine phosphatases. Par exemple, la PTPsigma joue un rôle dans la réparation de la moelle épinière, une découverte majeure et prometteuse pour les personnes atteintes de lésions médullaires. La PTP-TC est également importante dans les réponses du système immunitaire et dans la formation des cellules souches. Les recherches du professeur Tremblay ont ouvert de nouvelles avenues thérapeutiques. Il est un véritable pionnier de la science. Son approche entrepreneuriale et enthousiaste envers la recherche fondamentale et ses impacts sur la santé humaine est une source d’inspiration pour nous tous. Communiqué court Le professeur Michel L. Tremblay est un expert mondial des protéines tyrosine phosphatases. Ses travaux remarquables sur cette importante classe d’enzymes en ont démontré le rôle dans le traitement du cancer, du diabète, et de l'obésité. Il est un véritable pionnier de la science. Son approche entrepreneuriale et enthousiaste envers la recherche fondamentale et ses impacts sur la santé humaine est une source d’inspiration pour nous tous.

Long Citation The nominee has transformed the understanding of fundamental mechanisms of synaptic transmission and neural plasticity serving essential roles in cognition and emotion. Three revolutionary discoveries define Dr. Wang's career. He first demonstrated that tyrosine phosphorylation modulates NMDA/glutamate receptor channels. Next he provided an entirely novel mechanism for regulating postsynaptic responsiveness via a rapid translocation of ion channel receptors from an intracellular pool to cell surface. He also discovered that redistribution of AMPA receptors between surface membranes and intracellular compartments is fundamental to synaptic plasticity. His most revolutionary discovery demonstrated that dopamine and GABA receptors influence each other via protein-protein interactions. These discoveries will guide development of novel drugs for modulation of aberrant synaptic plasticity related to mental illness. Short Citation Yu Tian Wang has transformed the understanding of fundamental mechanisms of synaptic transmission and neural plasticity serving essential roles in cognition and emotion. Dr. Wang's most revolutionary discovery demonstrated that dopamine and GABA receptors influence each other via protein-protein interactions. The discoveries made by Dr. Wang have been used to guide the development of novel drugs for modulation of aberrant synaptic plasticity related to mental illness.

Notice longue Les travaux d'Andrew Granville incluent de nombreuses contributions de première importance aux aspects combinatoire, algébrique, diophantien et analytique de la théorie des nombres. Granville s'attaque à des questions fondamentales, a résolu de plusieurs problèmes qui étaient demeurés ouverts depuis de nombreuses années et a reçu de nombreux honneurs. Sa recherche est toujours marquée par une grande originalité. Il a servi sur plusieurs comités nationaux et internationaux ainsi qu'au sein d'équipes de rédaction. Son impact auprès des jeunes scientifiques est remarquable; de plus, sa réputation comme organisateur d'événements scientifiques n'est plus à faire. Granville est aujourd'hui un des premiers mathématiciens canadiens et un des plus grands théoriciens des nombres analytiques au monde. Notice courte Les travaux d'Andrew Granville incluent de nombreuses contributions de première importance aux aspects combinatoire, algébrique, diophantien et analytique de la théorie des nombres. Granville s'attaque à des questions fondamentales, a résolu de plusieurs problèmes qui étaient demeurés ouverts depuis de nombreuses années et a reçu de nombreux honneurs. Granville est aujourd'hui un des premiers mathématiciens canadiens et un des plus grands théoriciens des nombres analytiques au monde.

Long Citation Adam Hitchcock has made pioneering contributions to near-edge x-ray absorption fine structure spectroscopy of core levels in molecules, surfaces and solids. His work includes analytical studies and instrumentation development, using both synchrotron radiation and laboratory-based sources. He is a leading contributor to the emergence of the new technique of scanning transmission x-ray microscopy as a high resolution imaging method for materials research, that is sensitive to both composition and chemical bonding. He has demonstrated scientific leadership in the development and planning of the Canadian Light Source as an internationally competitive new Canadian research facility. Short Citation Adam Hitchcock has made pioneering contributions to near-edge x-ray absorption fine structure spectroscopy of core levels in molecules, surfaces and solids. He is a leading contributor to the emergence of the new technique of scanning transmission x-ray microscopy as a high resolution imaging method for materials research. He has demonstrated scientific leadership in the development and planning of the Canadian Light Source as an internationally competitive new Canadian research facility.

Long Citation Dr. Li is a leading expert on Kolmogorov complexity, the dominant modern theory of randomness and information. His work has led to a new method for proving lower bounds and analyzing average-case complexity of algorithms, and to the solution of a number of long standing major open questions in computer science. Dr. Li is also an influential international leader in the development of bioinformatics algorithms and software. He and his coauthors have produced theorems, algorithms, and proofs that are included in major computational biology books, as well as software packages used widely. Short Citation Ming Li is a leading expert on Kolmogorov complexity. His work has led to a new method for proving lower bounds and analyzing average-case complexity of algorithms and to the solution of a number of long standing major open questions in computer science. He is an influential international leader in the development of bioinformatics algorithms and software who, along with his coauthors, has produced theorems, algorithms, and proofs that are included in major computational biology books and software packages used widely.

Long Citation Peter Stetson has developed computer software to facilitate the measurement of the brightness and colours of individual stars in stellar clusters and other areas of the sky in which the recorded images of the stars are crowded together, or overlapping. His software is much in demand and is used by astronomers all over the world. Stetson himself has applied it to the study of the ages of stars in our own Galaxy and in other galaxies and to the determination of the age of the universe from its expansion rate. On all these topics he is considered a leading authority. Short Citation Peter Stetson has developed computer software to facilitate the measurement of brightness and colours of individual stars in stellar clusters and other areas of the sky in which the recorded images of the stars are crowded together, or overlapping. The software is in high demand and is used by astronomers world-wide. Stetson himself has applied it to the study of the ages of stars and to the determination of the age of the universe from its expansion rate. On all these topics he is considered a leading authority.