Dr. Cinader's numerous scientific contributions over the last two decades represent fundamental cornerstones for the elucidation of molecular, genetic and cellular factors of the immune response. His original studies on immunologic tolerance led him to postulate the theory of a 'steering mechanism', which explains the relationship between the specificity of the antibody response and tolerance to autologous macromolecules in terms of molecular concepts. The predictive value of his theory was borne out in studies of antibodies to enzymes, in the analysis of the specificity of isologous antibodies and in the analysis of the inheritance of immunological responsiveness. Cinader discovered a complement defect in inbred strains of mice which led him to enunciate the criteria for the analysis of inborn errors of metabolism. He also isolated an activating antibody directed against rlbonuclease, which was shown to induce a conformational chance In the antigen. From his studies of the genetic aspects of antibody formation with populations of antibody forming cells, he concluded that this process was a consequence of allelic interactions and that only one of the two genes of the diploid cell was activated in antibody formation. His work has been acclaimed throughout the world and he has been instrumental in establishing the Canadian Society for Immunology.

Howard C. Clark is an outstanding scientist and is a dedicated servant of science in his University and at the provincial and national levels. His 150 scientific papers describe pioneering work in several areas of inorganic and organometallic chemistry which are of great importance from both a scientific and practical point of view. He is internationally recognized as a leading figure in research in these areas. Through his service on provincial and national committees he has done much to encourage and support teaching and research in chemistry, and has fostered a high level of social responsibility in his scientific colleagues.