Dr. Gary D. Lopaschuk
Fellow
Current Employer
University of Alberta
Election Year
2007
Academy
Academy of Science
Discipline
Medical Sciences
Department
Department of Pediatrics and Pharmacology
Keywords
Fatty acid oxidation, heart disease, energy metabolism, Malonyl CA, Glucose oxidation
Long Citation
Gary Lopaschuk is a scientific leader in the area of how energy metabolism is controlled in the heart under both normal and pathological conditions. His research has clarified the molecular mechanisms responsible for the rapid maturation of fatty acid oxidation in the heart following birth and the high rates of fatty acid oxidation in the myocardium of the diabetic, as well as how excess use of fatty acids by the heart contributes to ischemic heart disease. Dr. Lopaschuk demonstrated that alterations in the control of fatty acid oxidation contribute to a number of cardiac pathologies, including ischemic heart disease, hypertrophy and heart failure, and diabetic cardiomyopathies. He has also shown that modifying fatty acid oxidation is a novel approach to treating various forms of heart disease. He is an inventor on a number of patents and has a prolific publication record.
Short Citation
Gary Lopaschuk is a scientific leader in the area of how energy metabolism is controlled in the heart under both normal and pathological conditions. His research has clarified the molecular mechanisms responsible for the rapid maturation of fatty acid oxidation in the heart following birth and the high rates of fatty acid oxidation in the myocardium of the diabetic, as well as how excess use of fatty acids by the heart contributes to ischemic heart disease.
Gary Lopaschuk is a scientific leader in the area of how energy metabolism is controlled in the heart under both normal and pathological conditions. His research has clarified the molecular mechanisms responsible for the rapid maturation of fatty acid oxidation in the heart following birth and the high rates of fatty acid oxidation in the myocardium of the diabetic, as well as how excess use of fatty acids by the heart contributes to ischemic heart disease. Dr. Lopaschuk demonstrated that alterations in the control of fatty acid oxidation contribute to a number of cardiac pathologies, including ischemic heart disease, hypertrophy and heart failure, and diabetic cardiomyopathies. He has also shown that modifying fatty acid oxidation is a novel approach to treating various forms of heart disease. He is an inventor on a number of patents and has a prolific publication record.
Short Citation
Gary Lopaschuk is a scientific leader in the area of how energy metabolism is controlled in the heart under both normal and pathological conditions. His research has clarified the molecular mechanisms responsible for the rapid maturation of fatty acid oxidation in the heart following birth and the high rates of fatty acid oxidation in the myocardium of the diabetic, as well as how excess use of fatty acids by the heart contributes to ischemic heart disease.