Dr. Jack Greenblatt
Fellow
Current Employer
University of Toronto
Election Year
1992
Academy
Academy of Science
Discipline
Molecular Biology and Genetics
Department
Terrence Donnelly Centre of Cellular and Biomolecular Research
Keywords
Gene regulation, protein interactions, genetic interactions, chemical genomics, systems biology
Jack Greenblatt, University of Toronto, has used difficult biochemical techniques including protein affinity chromatography, to elucidate fundamental mechanisms that control gene expression, especially the roles of proteins that associate with RNA polymerase in bacteria and humans. By focusing on the structure and function of multiprotein complexes he has pioneered breakthroughs in understanding of transcription elongation and termination in prokaryotes and of transcription initiation in eukaryotes.