Profile
Dr. Morag Park
Affiliation
McGill UniversityAcademy or College
Academy of ScienceYear Elected
2007Areas of Interest
receptor tyrosine, kinase, signaling, invasion, tumor microenvironment, breast cancer
Long Citation
Morag Park is an international leader in the fields of receptor tyrosine kinase signalling in epithelial invasion and cancer. She isolated the Met receptor tyrosine kinase and pioneered its use to understand the mechanisms of its activation in human cancer. She discovered constitutive dimerization for oncogene activation of receptor tyrosine kinases and demonstrated the importance of ubiquitylation in the downregulation of Met and as a paradigm for oncogenic activation of tyrosine kinases in human cancer. She uncovered signals that involve the scaffold protein Gab1 that regulate invasion in epithelial models applicable to metastasis. Her work now focuses on the tumour microenvironment relevant to human breast cancer.
Short Citation
Morag Park is an international leader in the fields of receptor tyrosine kinase signalling in epithelial invasion and cancer. Through her work she isolated the Met receptor tyrosine kinase and pioneered its use to understand the mechanisms of its activation in human cancer. She also discovered constitutive dimerization for oncogene activation of receptor tyrosine kinases. Her current work focuses on the tumour microenvironment relevant to human breast cancer.