GIGUÈRE, Vincent -, The Rosalind and Morris Goodman Cancer Centre, McGill University
Vincent Giguère is an international leader in the field of nuclear receptors, a class of DNA-binding proteins that regulate the expression of genes in a cell and tissue-specific manner in response to small lipophylic molecules such as steroid hormones and vitamin A. Dr. Giguère identified several members of the super-family of nuclear receptors and revealed mechanisms demonstrating how these proteins work at the molecular level. His groundbreaking work also led to major advances in our understanding of the roles played by nuclear receptors and their natural and synthetic ligands in embryonic development, adult physiology and several diseases, most notably hormone-dependent cancers and metabolic disorders.