Dr. Naranjan Dhalla
Fellow
Current Employer
University of Manitoba
Election Year
2000
Academy
Academy of Science
Discipline
Medical Sciences
Department
Institute of Cardiovascular Sciences
Keywords
Heart failure, Ischemic heart disease, diabetic cardiomyopathy, cardiac hypertrophy, stress-induced heart disease.
Naranjan S. Dhalla is known for his pioneer work on the pathophysiology of heart disease in general and subcellular defects leading to the development of cardiac contractile failure in particular. His research has shown that membrane abnormalities depend upon the type and stage of heart disease. Extensive work from his laboratory regarding remodelling of subcellular organelles in congestive heart failure as well as heart dysfunction in chronic diabetes now forms the basis for newer therapeutic strategies. He also demonstrated that stress-induced coronary spasm, arrhythmia, contractile failure and cell damage are due to the formation of oxidation products of catecholamines.