Dr. Siminovitch’s discoveries of genetic and molecular pathways underpinning immunologic diseases have elucidated new paradigms of signal transduction and cell biology, illuminating the mechanisms whereby selected classes of signal transducting effectors link extracellular stimuli to cytoskeletal-driven cell responses or to the attenuation of cell responses required for homeostasis. Her discoveries of molecular pathways responsible for autoimmune disease have also profoundly advanced understanding and potential to ameliorate these common debilitating diseases.