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Dr. Adrian Brook
Affiliation: University of Toronto
Keywords: Chemistry, computing
Deceased Date: 2013-07-10
Dr. Brook has an international reputation in organosilicon chemistry. His extensive studies of silanes bearing functional groups have resulted in important new synthetic methods and in the elucidation
of the nature of the bonding in organosilicon compounds. He discovered the rearrangement of a-hydroxysilanes to silyl ethers, and his investigation of the mechanism of this reaction led to the first
demonstration of the absolute configuration of asymmetric silanes. His work on the rearrangement of acylsilanes to siloxycarbenes has culminated in the discovery of a highly versatile method for the
generation and isolation of a stable compound containing the elusive silicon-carbon double bond.
Dr. John Brosnan
Affiliation: Memorial University of Newfoundland
Keywords: B Vitamins, Creatine, Amino Acids, Metabolism
Induction Year: 2009
Deceased Date: 2024-12-04
John Brosnan has discovered important basic mechanisms in amino acid metabolism that also address crucial clinical issues. His discoveries have led to novel approaches for the preservation of organs for transplantation.
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BROSNAN, John T. –Department of Biochemistry, Memorial University
John Brosnan has discovered important basic mechanisms in amino acid metabolism that also address crucial clinical issues. He discovered the mechanism of regulation of circulating homocysteine levels. His concept of methylation demand has led to novel approaches to reduce those elevated homocysteine levels that can contribute to stroke, Alzheimer's disease and diabetic complications. He discovered mechanisms of regulation of the synthesis and catabolism of arginine, the NO precursor. His work on creatine is particularly important for infant nutrition and catabolic illnesses, while his discovery that renal function is protected by amino acids has led to novel approaches for the preservation of organs for transplantation.
Dr. A. Brown
Affiliation: Michigan State University
Keywords: Toxicology
Disease
Vectors
Entomology
Control
Deceased Date: 2005-02-17
A. W. A. Brown, M.B.E., B.Sc.F., M.A., Ph.D., has given leadership, with sound scholarship and originality in research, in the field of Entomology, not only to Canada but internationally. He has had remarkably wide interests and training, obtaining degrees in Forestry, Zoology, and Biochemistry. His numerous papers and books on Insect Physiology, Biochemistry, and chemical control of pests are internationally recognized as authoritative. He has served as expert consultant, not only in Canada but for Britain, the United States, and the World Health Organization. Dr. Brown has contributed greatly as Head of the Zoology Department of the University of Western Ontario, as editor of many journals, and as an officer in scientific societies.
Dr. John Brown
Affiliation: The University of British Columbia
Keywords: Juvenile diabetes, Type II diabetes, obesity
Deceased Date: 2016-10-15
Dr. Brown is an imaginative and highly competent young scientist who has made major contributions to the field of gastrointestinal physiology through his discovery, isolation, determination of the amino acid structure, and development of radioimmunoassays of two new peptide hormones from the gut, 'Gastric Inhibitory Polypeptide (GIP)' and 'Motilin'. The former has the properties of 'enterogastrone', the hypothetical substance which inhibits acid gastric secretion and stomach emptying when fat enters the duodenum, and 'incretin', which stimulates insulin secretion when glucose is introduced into the duodenum. Motilin is released and stimulates gastric motility when the duodenal contents are alkaline, thus controlling pH. Clinical studies have continued the insulinotropic action of GIP in man and demonstrated that IRGIP is elevated in chronic pancreatitis, maturity onset diabetes and obesity. Thus GIP is very relevant to the problem of diabetes.
Robert Brown
Affiliation: University of Toronto
Deceased Date: 2016-09-22
Robert Craig Brown's books and scholarly articles, taken together, constitute a first-rank contribution to the history of modern Canada. His primary interest has been in the period since 1896, and he is the co-author of "Canada Since 1896", the standard book on that critical era, one of the finest volumes in the Centenary Series published by McClelland & Stewart. His biography of Sir Robert Borden, published in two volumes in 1975 and 1980, is a massive work of resarch and analysis, a major reinterpretation of early 20th Century Canada, and one of the best biographies of a major political figure since Creighton's "Macdonald". This work, like all of Brown's publications, is characterized by scrupulous scholarship, balanced judgment and careful attention to the niceties of language. Professor Brown has been editor of the "Canadian Historical Review" and president of the Canadian Historical Association, and President of the Academy of Humanities and Social Sciences of the Royal Society of Canada.
Dr. W. Robert Bruce
Affiliation: University of Toronto
Keywords: Carcinogenesis, colon, breast, diet, oxidative stress
Deceased Date: 2022-01-15
Dr. W.R. Bruce has made important contributions to medical research in three areas: First, by comparing the effects of chemotherapeutic agents on the proliferative capacity of normal and malignant cells, he devised a model to explain the action of drugs used in the treatment of human cancer. Second, by combining physical separation techniques with radioactive labelling, he traced the differentiation events that occur in the testis. He has applied this knowledge to develop a rapid and sensitive method for detecting the mutagenic effects of chemicals. Third, he developed computer programmes for clinical use in the many treatment centres operated by the Ontario Cancer Treatment and Research Foundation. This achievement not only permits the evaluation of cancer care in Ontario, but also provides a model for multi-centre assessment of results that can be applied widely and to many other diseases.
Fourth, he has explored the development of Colon Cancer: identifying with J. Krepinsky the major fecal ....., ...., with R.P. Bird the ...... Crypt focus, the ...... colon cancer precursor; developing a .... trial methodology based on recurrence of clonic polyps; and exploring the relation between colon cancer and insulin resistance.
Dr. Thomas Brzustowski
Affiliation: University of Ottawa
Keywords: Innovation, invention, commercialization, R&D
Deceased Date: 2020-06-19
Dr. Thomas A. Brzustowski has made distinctive and lasting contributions to science and technology in Canada via activities in: scholarly research, teaching and academic administration; public policy on postsecondary education and knowledge based economic renewal; and outstanding leadership to the university research community as President of the Natural Sciences and Engineering Research Council (NSERC). An aeronautical and mechanical engineer, Dr. Brzustowski achieved international recognition for his pioneering research on combustion processes and flames. In October 1987, he joined the government of Ontario as Deputy Minister of Colleges and Universities, the senior civil servant in charge of postsecondary education. His success led to a new and important role as Deputy Minister for the Premier's Council on Economic Renewal. He joined NSERC as president in
1995.