Prof. R. Keith Poole
Fellow
Current Employer
Queen's University
Election Year
2015
Academy
Académie des sciences
Discipline
Microbiology and Biochemistry
Department
Department of Biomedical and Molecular Sciences
Keywords
antibiotic resistance
Updated July 20, 2015
POOLE, Keith, Department of Biomedical and Molecular Sciences, Queen's University
Keith Poole, Professor of Microbiology at Queen’s University, has made fundamental contributions to understanding the interplay between basic bacterial physiology and infectious disease. Importantly, he discovered a family of antibiotic pumps that export multiple antimicrobials out of the bacterium, P. aeruginosa. These so-called multidrug pumps are common in disease-causing bacteria and their discovery has revolutionized the field of antimicrobial chemotherapy and resistance and influenced antibiotic development in the pharmaceutical industry.
POOLE, Keith, Department of Biomedical and Molecular Sciences, Queen's University
Keith Poole, Professor of Microbiology at Queen’s University, has made fundamental contributions to understanding the interplay between basic bacterial physiology and infectious disease. Importantly, he discovered a family of antibiotic pumps that export multiple antimicrobials out of the bacterium, P. aeruginosa. These so-called multidrug pumps are common in disease-causing bacteria and their discovery has revolutionized the field of antimicrobial chemotherapy and resistance and influenced antibiotic development in the pharmaceutical industry.
Keith Poole, professeur de microbiologie à l'Université Queen's, a contribué fondamentalement à la compréhension des interactions entre la physiologie bactérienne et les maladies infectieuses. La découverte des pompes à antibiotiques exportant de multiples substances antimicrobiennes hors de la bactérie P. aeruginosa fut des plus significatives. Ces pompes multi-drogues sont communes dans les bactéries pathogènes et leur découverte a révolutionné les domaines de la chimiothérapie et de la résistance antimicrobienne, de même qu'influencé le développement d'antibiotiques dans l'industrie pharmaceutique.