Dr. Sergio Grinstein
Fellow
Current Employer
University of Toronto
Election Year
2000
Academy
Académie des sciences
Discipline
Microbiology and Biochemistry
Department
Department of Cell Biology
Keywords
Ion transport, pH regulation, signal transduction, leukocyte biology, phagocytosis
Sergio Grinstein's is an expert on ion transporters and their roles in intracellular homeostasis, namely, the control of cell volume and of intra-cellular and intraorganelle parameters such as pH and calcium concentration. He has devised methods for the measurement of pH in individual subcellular compartments within living cells. These and other remarkable methods have been widely used by his group and by others to study intracellular homeostasis. He has also made important contributions to the understanding of how white blood cells are activated to destroy microbial invaders. Dr. Grinstein has published over 280 papers since 1974 as well as many book chapters and reviews. He has given numerous invited lectures at international conferences and is recognized by his peers as an international authority in his field.