Dr. John Brosnan
Fellow
Current Employer
Memorial University of Newfoundland
Election Year
2009
Academy
Académie des sciences
Discipline
Microbiology and Biochemistry
Department
Department of Biochemistry
Keywords
B Vitamins, Creatine, Amino Acids, Metabolism
John Brosnan has discovered important basic mechanisms in amino acid metabolism that also address crucial clinical issues. His discoveries have led to novel approaches for the preservation of organs for transplantation.
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BROSNAN, John T. –Department of Biochemistry, Memorial University
John Brosnan has discovered important basic mechanisms in amino acid metabolism that also address crucial clinical issues. He discovered the mechanism of regulation of circulating homocysteine levels. His concept of methylation demand has led to novel approaches to reduce those elevated homocysteine levels that can contribute to stroke, Alzheimer's disease and diabetic complications. He discovered mechanisms of regulation of the synthesis and catabolism of arginine, the NO precursor. His work on creatine is particularly important for infant nutrition and catabolic illnesses, while his discovery that renal function is protected by amino acids has led to novel approaches for the preservation of organs for transplantation.
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BROSNAN, John T. –Department of Biochemistry, Memorial University
John Brosnan has discovered important basic mechanisms in amino acid metabolism that also address crucial clinical issues. He discovered the mechanism of regulation of circulating homocysteine levels. His concept of methylation demand has led to novel approaches to reduce those elevated homocysteine levels that can contribute to stroke, Alzheimer's disease and diabetic complications. He discovered mechanisms of regulation of the synthesis and catabolism of arginine, the NO precursor. His work on creatine is particularly important for infant nutrition and catabolic illnesses, while his discovery that renal function is protected by amino acids has led to novel approaches for the preservation of organs for transplantation.
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