Dr. David Goltzman

Dr. Goltzman is internationally recognized for his work on calcium and bone metabolism. He initiated structure - function studies of parathyroid hormone (PTH), and identified its cellular target in skeletal tissue. He introduced the concept of calcitonin as a neuropeptide and delineated CNS receptors for it and related peptides. He pioneered methods leading to the discovery of PTH-related peptide (PTHRP), isolated the genes encoding PTHRP, and elucidated their regulation. His work was key in establishing PTHRP as a widespread mediator of the hypercalcemia of malignancy and in demonstrating its essential role for normal skeletal development. He has thus provided an understanding of important aspects of calcium metabolism in both health and disease.